Gene mutation in ATM/PI3K region of nasopharyngeal carcinoma cell lines
- VernacularTitle:不同放射敏感性的鼻咽癌细胞中ATM/PI3K区基因突变的研究
- Author:
Hongmei WANG
;
Xinyao WU
;
Yunfei XIA
- Publication Type:Journal Article
- Keywords:
CNE cell line;
Radiosensitivity;
ATM gene
- From:
Chinese Journal of Radiation Oncology
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To define the correlation between nasopharyngeal carcinoma (NPC) cell radiosensitivity and gene mutation in the ATM/PI3K coding region. Methods The gene mutation in the ATM/PI3K region of nasopharyngeal carcinoma cell lines which vary in radiosensitivity,was monitored by reverse transcription polymerase chain reaction (RT PCR) and fluorescence marked ddNTP cycle sequencing technique.Results No gene mutation was detected in the ATM/PI3K region of either CNE1 or CNE2.Conclusion Disparity in intrinsic radiosensitivity between different NPC cell lines depends on some other factors and mechanism without being related to ATM/PI3K mutations.
