PREPARATION OF CHITOSAN FILM AND STUDY ON ITS HEMOSTATIC PROPERTIES
- VernacularTitle:几丁糖膜的制备及其止血性能的研究
- Author:
Qingqing SI
;
Chunlin HOU
;
Lixi JIANG
- Publication Type:Journal Article
- Keywords:
chitosan film;
preparation;
hemostasis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to prepare chitosan film and to study its hemostatic properties. Chitosan film was prepared by casting the mixed solution of dialysed chitosan and gelatin after crosslinking with glutaraldehyde in a freeze dryer. Bleeding times were measured for bilateral back incisions (5 incisions on each side) in 4 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan film, the other was treated with gauze. After bleeding stopped ,hemoglobin amount in films or gauzes was measured to determine the hemostatic effect. The results showed that the chitosan film adhered well to incisions. Bleeding times and hemoglobin amounts in chitosan film group were superior to those in gauze group( P
