HISTOLOGICAL CHANGES IN NORMAL RAT BRAIN AFTER GAMMA IRRADIATION
- VernacularTitle:伽玛刀照射后正常大鼠脑形态学变化的观察
- Author:
Qiang ZHONG
;
Zonghui LIU
;
Xi YU
- Publication Type:Journal Article
- Keywords:
Gamma knife;
cranial irradiation;
morphology;
rats;
radiosurgery
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To study time and dose related changes after gamma knife radiosurgery (GKR) in rat brain, right caudate nucleuses of rats were irradiated by OUR XGD gamma units. The maximum dosages of 20,50,75 and 160Gy were given using a 4 mm collimator. HE, Nissl, Luxol fast blue staining and immunohistochemistry were utilized to observe histological changes.Histological changes in the right caudate nucleuses such as microvessel injury, which appeared as telangiectasia, vasodilatation, vessel wall thickening and edema, and astrocyte changes, which appeared as hypertrophy and proliferation, were observed at various time points after GKR. These findings demonstrate time dependent and dosage dependent changes are found in normal cerebral tissue after GKR. These results provide an explanation of the process taking place during the latent period before delayed radiation necrosis develops.
