EFFECT OF ACID INHIBITOR ON THE FUNCTION AND ULTRASTRUCTURE OF GASTRIC PARIETAL CELLS IN RATS UNDER STRESS
- VernacularTitle:抑酸剂对应激状态下壁细胞形态及功能的影响
- Author:
Yumei LI
;
Zhaoshen LI
;
Xiaopin ZOU
- Publication Type:Journal Article
- Keywords:
stress;
gastric mucosa;
peptic ulcer;
parietal cell, gastric;
acid inhibitor
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to demonstrate the effect of acid inhibitor on the function and ultrastructure of gastric parietal cells in rats under immersion and restraint stress. Thirty two male SD rats were randomly divided into control, stress, omeprazole and cimetidine treated groups. The gastric mucosal ulcer index (UI) and gastric juice pH were measured. The ultrastructural changes of parietal cells were observed by transmission electronic microscopy (TEM). The UI was decreased and the pH value was increased obviously in omeprazole and cimetidine treated groups compared with stress group ( P
