THE EXPRESSION OF METALLOPROTEINASES 2 AND 9 AND THE PROGNOSIS IN HUMAN RENAL CELL CARCINOMA
- VernacularTitle:肾癌组织中基质金属蛋白酶的表达与肿瘤预后的关系
- Author:
Yeyong QIAN
;
Bingyi SHI
;
Yanji XU
- Publication Type:Journal Article
- Keywords:
kidney neoplasms;
matrx metalloproteinases;
prognosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the expression of matrical metalloproteinases 2 and 9 (MMP 2 ,MMP 9 ) in human renal cell carcinoma(hRCC) and its relation to prognosis, 36 specimens of human renal cell carcinoma (hRCC) and 6 normal kidneys served as controls were assessed by immunohistochemistry (SP method). The results showed that the positive expression rates of MMP 2 , MMP 9 in hRCC were 44 4% and 52 8%,respectively. There was a significant difference in expression between various grades and stages of hRCC. The expected survival time was shorter in patients with higher expresson of MMP 2 and MMP 9 . Therefore, MMP 2 and MMP 9 are considered as important factors in invasive metastasis and prognosis of hRCC.
