ANALYSIS OF HEMATOPOIETIC CHIMERISM STATE AFTER ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION
- VernacularTitle:异基因外周血造血干细胞移植后造血细胞嵌合状态的分析
- Author:
Bo YAO
;
Qiyun SUN
;
Shuqion JIA
- Publication Type:Journal Article
- Keywords:
leukemia;
hematopoietic stem cells transplantation;
chromosomes;
polymerase chain reaction
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate engraftment state after allogeneic peripheral blood stem cell transplantation (ALLO PBSCT), 30 patients who received ALLO PBSCT were studied using cytogenetic analysis and short tandem repeats polymerase chain reaction (STR PCR). Twenty one of the 23 patients who received sex mismatched donor marrows showed complete chimerism (CC), one showed mixed chimerism (MC), and one showed completely recipient karyotype. In the 7 patients of chronic myelogenous leukemia (CML) who received sex matched donor marrows, except 2 patients, the rest showed completely disappearance of Ph positive cells. The results from these two detection methods completely coincided mutually. STR PCR and cytogenetic analysis can be supplementary to each other and their results can be pooled together.
