Effect of Metformin Treatment and Insulin Resistance in Patients with Polycystic Ovary Syndrome.
- Author:
Kyu Ri HWANG
1
;
Young Min CHOI
;
Doo Seok CHOI
;
Kwang Hyun BAEK
;
Hye Won JEON
;
Kwang Bum BAE
;
Young Soo SON
;
Seung Yup KU
;
Byung Chul JEE
;
Chang Suk SUH
;
Seok Hyun KIM
;
Jung Gu KIM
;
Shin Yong MOON
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
Metformin
- MeSH:
Female;
Humans;
Insulin Resistance*;
Insulin*;
Menstruation;
Metformin*;
Ovulation;
Periodicity;
Polycystic Ovary Syndrome*;
Seoul
- From:Korean Journal of Obstetrics and Gynecology
2004;47(10):1949-1953
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was performed to investigate the effect of metformin treatment and insulin resistance in the patients with polycystic ovary syndrome. METHODS: Twenty three patients with polycystic ovary syndrome were included at Seoul National University Hospital from September 2001 to September 2003. Metformin was administered at daily 1,500 mg for 3 months to these patients. Then restoration of regular menstruation or recovery of ovulation was evaluated and insulin resistance was compared between the responder and the non-responder before and after metformin treatment. RESULTS: Eleven patients (47.8%) showed a significant improvement in menstrual or ovulation cyclicity whereas twelve patients had no change. There was no statistically significant difference in the insulin resistance between the responder and the non-responder before and after metformin treatment. CONCLUSION: In non-obese patients with polycystic ovary syndrome, metformin treatment seems to be effective to improvement of menstrual or ovulation cyclicity irrespective of insulin resistance expressed as glucose-to- insulin ratio and HOMA.
