Relationship between cell apoptosis, proliferating cell nuclear antigen (PCNA) expression and biological behavior of human colorectal neoplasms
- VernacularTitle:细胞凋亡及增殖细胞核抗原表达与大肠肿瘤生物学行为的关系
- Author:
Liqun PANG
;
Naiyuan XU
;
Jianming ZHENG
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
proliferating cell nuclear antigen i apoptosis;
biological behavior
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the apoptosis and the expression of proliferating cell nuclear antigen (PCNA) in colorec-tal neoplasms and their relationship with neoplasm biological behavior. Methods: Apoptotic index (AI) and proliferative index (PI) were determined in paraffin-embedded tissues from 62 cases of colorectal carcinomas, 15 cases of colon adenomas and 10 cases of normal colon mucosa with immunohistochemistry S-P method and TUNEL technique. Results: The difference of PI and AI was significant in normal colon mucosa, colon adenomas and colorectal carcinomas (P
