Pharmacokinetics of fluoroful temperature-sensitive liposome in rabbits
- VernacularTitle:替加氟温度敏感性脂质体家兔体内动力学
- Author:
Qianzhuo LU
;
Chuan ZHANG
- Publication Type:Journal Article
- Keywords:
fluoroful;
temperature-sensitive;
liposomes;
pharmacokinetics
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pharmacokinetics of fluoroful temperature-sensitive liposomes in rabbits. Methods: Fluoroful temperature-sensitive liposomes were intravenously administered into rabbits. Livers were heated to (42?0.1)℃ by microwave, blood concentrations of fluoroful were determined, the pharmacokinetics parameters of it were calculated. Results: After being heated, the drug releasing of fluoroful temperature-sensitive liposomes was accelerated, and the drug were controlled to be released into liver. Conclusion: Fluoroful temperature-sensitive liposomes can be controlled to release specifically into livers by heating the organs.
