THE CHANGES OF MYOCARDIAL ULTRASTRUCTURE AND CELL MEMBRANE CHANNEL IN UREMIC RATS
- VernacularTitle:尿毒症大鼠心肌超微结构和细胞内钙离子代谢的变化
- Author:
Jianzhong MENG
;
Kanfu PENG
;
Min GENG
- Publication Type:Journal Article
- Keywords:
uremia;
myocardium;
calcium;
rats
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to explore the myocardial ultrastructure of experimental uremic rats and the effect of myocardiocyte succinate dehydrogenase(SDH) and free cytosolic calcium changes on membrane channel. By making a uremia model in rats, changes of SDH activation was observed by quantitative enzyme cytochemistry methods and membrane calcium channel was checked by laser scanning confocal microscopy. The results showed that with the uremia becoming heavier, myocardiocyte membrane was rolled and broken, myofibrils were swollen and broken. The quantity of mitochondria with SDH products significantly decreased, while activation of cell membrane calcium channel markedly increased and cytosolic calcium piled up. It is suggested that impaired myocardial membrane, decreased contents of mitochondrial function enzyme and cytosolic calcium overload are the pathophisiological basis leading to cardiac dysfunction in uremia.
