THE RESEARCH OF FIVE DRUG-RESISTANCE GENES OF MYCOBACTERIUM TUBERCULOSIS IN 134 PATIENTS
- VernacularTitle:134例结核杆菌5种耐药基因的检测
- Author:
Hongmin LI
;
Xueqiong WU
;
We WANG
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
drug resistance;
genes;
PCR SSCP
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
M.tuberculosis strains isolated strains from sputum specimens of 134 patients were analyzed by PCR SSCP and traditional drug susceptibility tests. The results sbowed that the gene mutation rate of PZA, SM, RFP,INH and EMB resistance in those clinically isolated strains was 42 7%,71 7%,78 9%,68 6% and 43 9%, respectively. The gene mutation was in relation with drug resistance level of M. tuberculosis. The gene mutation rate was higher in high concentration resistance strains than in low concentration resistance strains.
