EFFECT OF LIVER TRANSPLANTATION ON GASTRIC MUCOSAL LESIONS AND ITS SIGNIFICANCE
- VernacularTitle:肝移植对胃粘膜损伤的影响及意义
- Author:
Shengzhi WANG
;
Qingjiu MA
;
Yanku CHU
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
liver transplantation;
gastric mucosa;
oxygen free radicals;
interleukin;
prostaglandin
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect of liver transplantation on gastric mucosa lesions and the changes in plasma superoxide dismutase(SOD),malondialdehyde(MDA),interleukin 1(IL 1) and prostaglandin(PG) between before and after liver transplantation, a hepatic cirrhosis model was established in rats by subcutaneous injection of 40% carbon tetrachloride. Rat liver transplantation was made with the two cuff technique. By immunohistochemical method,we observed the effect of liver transplantation on rat gastric mucosa lesions. Using chemical method the changes in plasma SOD, MDA,IL 1 and PG between before and after liver transplantation were observed.The results showed that gastric mucosal lesions alleviated significantly after liver transplantation in rats with liver cirrhosis,and lesion index decreased gradually.The plasma levels of SOD decreased,MDA increased,and the plasma levels of IL 1, PGE 2 increased gradually after liver transplantation. Therefore, liver transplantation can improve gastric mucosal lesion, and this effect may be connected with its action on oxygen radicals, PG and IL 1.
