A COMPARITIVE STUDY BETWEEN SINGLE DRUG AND MULTIDRUG-COMBINATION IN SUSCEPTIBILITY TEST FOR MYCOBACTERIUM TUBERCULOSIS
- VernacularTitle:结核杆菌单药敏感试验与多药联合敏感试验比较研究
- Author:
Tieji KUANG
;
Mei DONG
;
Pin SONG
- Publication Type:Journal Article
- Keywords:
drug susceptibility testing;
Mycobacterium tuberculosis;
multidrug combination susceptibility testing
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
The results of drug activity of singe drug and multidrug combination susceptibility tests showed the coincidence rate between the two kinds of tests was above 95% . The results also indicated that the chemotherapy program consisted of resistant drugs exhibited an inhibitory effects to different extents on the growth of 40% strains in vitro. Using two resistant drugs and one susceptible drug in the susceptibility test of three drug combination assay the pathogenic strain was still susceptible. It is proved that the extents of susceptibility of pathogenic strains to chemotherapy programs could be accurately calculated by the time of initial growth , the colony count and the colony size in multidrug combination susceptibility test. The results suggested Kuang′s agar medium should be adapted in the drug susceptibility test and the multidrug combination susceptibility test should be carried out for multidrug resistant strains of Mycobacterium tuberculosis.
