STUDY ON CELL APOPTOSIS GENES IN PULMONARY TISSUE OF TAIL-SUSPENDED RATS DURING SIMULATED WEIGHTLESSNESS
- VernacularTitle:尾悬吊模拟失重大鼠肺组织细胞凋亡调控基因的研究
- Author:
Junfeng WANG
;
Changting LIU
;
Delong WANG
- Publication Type:Journal Article
- Keywords:
simulated weightlessness;
suspension;
gene expression regulation;
pulmonary tissues
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the changes of cell apoptosis genes in pulmonary tissue of tail suspended rats during simulated weightlessness, 40 Spragno Dawley male rats were divided into 4 groups: suspended for 7d,control of 7d, suspended for 21d, and control of 21d.Tail suspension(-30?) was used as weightlessness simulation.The condition of bcl 2/bax in pulmonary tissues was detected by in situ hybridization. The results showed that the level of bcl 2 mRNA in pulmonary tissue of 7d tail suspended rats decreased significantly( P 0 05). The results also showed that the level of bax mRNA in pulmonary tissue of 7d tail suspended rats increased significantly( P 0 05).It can be concluded that there are certain changes of cell apoptosis genes in pulmonary tissue of 7d tail suspended rats during simulated weightlessness.
