EFFECT OF HYPERBARIC OXYGEN ON CONCENTRATION OF EXCITATORY AMINO ACIDS IN SPINAL CORD TISSUES OF RATS WITH SPINAL CORD INJURY
- VernacularTitle:高压氧对脊髓损伤大鼠脊髓组织中兴奋性氨基酸的影响
- Author:
Jian FANG
;
Tiesheng HOU
;
Yiqu FANG
- Publication Type:Journal Article
- Keywords:
spinal cord injuries;
hyperbaric oxygenation;
excitatory amino acids
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the mechanism of hyperbaric oxygen (HBO) on spinal cord injury (SCI), we duplicated a SCI model and determined the concentrations of excitatory amino acids [EAA, including aspartic acid (Asp) and glutamic acid (Glu)] in spinal cord tissue after treated with 0 1 MPa HBO, 0 25 MPa HBO, 0 25 MPa N 2 O 2 and hormone, respectively. The results showed that the concentration of EAA (Glu) in the spinal cord significantly increased after injury, whereas after treatment it decreased in all but the N 2 O 2 group. It decreased most significantly in 0 25MPa HBO and 0 25MPa HBO+hormone groups. There were significant differences between 0 25MPa HBO group and 0 1MPa HBO group, 0 25MPa HBO+hormone group and pure hormone group ( P
