CLINICAL FEATURES AND PATHOLOGY OF THE CENTRAL NERVOUS SYSTEM IN THROMBOTIC THROMBOCYTOPENIC PURPURA
- VernacularTitle:血栓性血小板减少性紫癜的临床神经精神表现和病理改变
- Author:
Mingwei ZHU
;
Luning WANG
;
Dingrong ZHONG
- Publication Type:Journal Article
- Keywords:
thrombotic thrombocytopenic purpura;
central nervous system;
pathological condition, signs and symptom
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To have a better understandings of the clinical features and pathology of the central nervous system of thrombotic thromocytopenic purpura(TTP) in order to avoid its misdiagnosis and improper treatment, we reported here the clinical features of the central nervous system of 2 cases with TTP and pathologic changes in the brain of one case of them.The result showed that in 2 young women presented with atypical clinical features and laboratory findings of TTP, the main presentations of the central nervous system included language disturbances, hemiplegia, delirium, scream, confusion, unconsciousness.Both of them had an acute progresive course. One case died after steroids therapy alone and the other got complete remissions after conbined treatment with plasmapheresis and steroids. Pathological examination of the brain of the died case showed widespread hyaline thrombosis in small vessels and ischaemic changes of the neurons in the hippocampus and the cerebral cortex. Our conclusion is there are various patterns of clinical presentations of the CNS in TTP and the disturbances are due to widespread thrombotic microangiopathy and failure of cerebral perfusion.
