Progress of Listeria monocy togenes as tumor vaccine vector
10.3969/cjz.j.issn.1002-2694.2014.07.016
- VernacularTitle:单核细胞增生性李斯特菌作为肿瘤疫苗运送载体的研究进展
- Author:
Feifei DUAN
;
Yuelan YIN
;
Meiqin KANG
;
Weijun TAN
;
Chengwu TAO
;
Zhiming PAN
;
Jinlin HUANG
;
Xinan JIAO
- Publication Type:Journal Article
- Keywords:
Listeria monocytogenes;
vaccine vector;
tumor
- From:
Chinese Journal of Zoonoses
2014;(7):743-746,752
- CountryChina
- Language:Chinese
-
Abstract:
Listeriamonocytogenes is a facultative intracellular bacterium that enters professional antigen presenting cells , presents passenger antigens to the major histocompatibility complex class I and II pathways ,then elicits CD+4 and CD+8 T-cell-mediated immune responses .It was demonstrated that attenuated Listeriamonocytogenes as a novel live vaccine vector in deliv-ering tumor antigens of cervical cancer and melanoma etc .,could induce strong protective immune response ,and shows effec-tive antitumor immunotherapeutics .This review discussed the characteristics of immune responses elicited by Listeria monocy-togenes ,and the progress of its antitumor immunotherapeutics as delivery vaccine vector .
