Effect of viral factors and host cellular immunity on the response to interferon in the patients with chronic hepatitis C
- VernacularTitle:慢性丙型肝炎患者病毒因素及宿主细胞免疫对干扰素治疗应答的影响
- Author:
Xiaoping TANG
;
Keping QIAN
;
Yiling XU
- Publication Type:Journal Article
- Keywords:
Hepatitis C;
Genotype;
Quasispecies;
Viremia;
T lymphocyte, cytotoxic;
Interferon alpha
- From:
Chinese Journal of Infectious Diseases
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the influence of viral factors and host cellular immunity on the response to interferon in the patients with chronic hepatitis C. Methods Forty patients with chronic hepatitis C were treated with interferon ?. The relationships between response to interferon a and HCV genotype, quasispecies heterogeneity, HCV RNA level and HCV specific cytotoxic T lymphocyte (HCV CTL) activity in the liver were analyzed. Results After 6 months of therapy, 21 patients had obtained end of treatment response (ETR), 10 Patients of which had obtained sustained response (SR). The other 19 patients got no response (NR). ETR rate in patients with genotype HCV1 infection (43.3%, 13/30) was significantly lower than that in patients with non HIV1 infection (80%, 8/10) [ P
