Analyses of clinical features of Glucocorticoid induced osteoporotic fractures in 14 children with rheumatic diseases
10.3760/cma.j.issn.1007-7480.2014.09.010
- VernacularTitle:风湿性疾病儿童激素诱导的骨质疏松症骨折14例临床特点分析
- Author:
Chao LI
;
Caifeng LI
- Publication Type:Journal Article
- Keywords:
Rheumatic diseases;
Child;
Hormones;
Osteoporosis;
Fractures,bone
- From:
Chinese Journal of Rheumatology
2014;18(9):623-626,652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features of rheumatic diseases patients with Glucocorticoid (GC) induced osteoporotic fractures.Methods Fourteen patients with GC induced osteoporotic fractures in Beijing Children's Hospital from January 2005 to December 2012 were retrospectively analyzed.The clinical features,spine radiographs/CT,dose of GC were analyzed.Results In various rheumatic diseases,systemic lupus erythematosus (SLE) and systemic onset juvenile idiopathic arthritis (SoJIA) were the most common related diseases.All children had no obvious causes of fracture.Eleven patients had back pain or limitation of activity.Fourteen patients had vertebral fractures.Seven cases had thoracic vertebral fracture,3 cases had fractures of lumbar vertebra.Four cases had multiple painful vertebral fractures.The time of fracture occurrence in patients received glucocorticoid therapy were between 5 months and 6.5 years.Daily minimum dose of glucocorticoid was 0.25-1.12 mg/kg and mean dose was 0.47-2.62 mg/kg.Conclusion GC induced osteo-porotic fractures is a serious complication of long-term use of glucocorticoid.Physicians taking care of children who have received long-term glucocorticoid therapy should be alert of the manifestation of osteo-porosis,such as back pain.
