EVALUATION ON THE INTERRELATIONSHIP BETWEEN SERUM sPTA1 LEVEL AND ACTUE ALLOGRAFT REJEC- TION IN RENEAL TRANSPLANTAION
- VernacularTitle:血清sPTA1(CD226)在判别肾移植术后急性排斥反应中的作用
- Author:
Zhouli LI
;
Bingyi SHI
;
Ming CAI
- Publication Type:Journal Article
- Keywords:
kidney transplantation;
sPTAl;
graft rejection
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the interrelationship between serum sPTA1 level and actue allograft rejection in renal transplantation, solid-phase lig-and ELISA method was used to analyze serum sPTAl level in renal transplantation. Five out of 19 patients after renal transplantation were confirmed haying actue allograft rejection by pathologic examination. The level of serum sPTA1 increased remarkably and the change in serum sP-TA1 level occurred earlier than appearance of clinical symptoms and in histopathologic manifestation. It decreased rapidly after enhancement of immune therapy. The allografts did not show any signs of acute rejection by clinic symptom and/or histopathology until the activation reached to a certain level. Therefore, the level of serum sPFA1 is a credibable guideline to recognize and monitor allograft renal transplantation. Its result is consistent with that of histopathological examination.
