STUDY ON LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN-1 IN RENAL ISCHEMIA-REPERFUSION INJURY IN RATS
- VernacularTitle:淋巴细胞功能相关抗原-1在肾脏缺血再灌注损伤中的作用
- Author:
Wei HONG
;
Hongwei BAI
;
Bingyi SHI
- Publication Type:Journal Article
- Keywords:
cell adhesion molecules;
lymphocyte function associated antigen-1;
kidney;
reperfusion injury
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the change in renal CD11a and myeloperoxidase (MPO) contents and renal function during ischemia-reperfusion injury (IRI) of rat kidney, as well as the role of lymphocyte function associated antigen-1 (LFA-1) played in renal IRI, we utilized a rat model of renal IRI to detect the renal tissue contents of CDlla and MPO and renal functioa The results showed that the levels of CD11a and MPO were very low in normal renal tissue, but increased significantly in ischemia reperfusion. Renal failure was presented in rats with IRI. The levels in the ischemia-60min-reperfusion group were higher than those in the ischemia-30min-reperfusion group in the same time points. Our conclusion is the levels of CD11a and MPO in rat renal tissue increase significantly during renal IRI. LFA-1-mediated leukocyte adherence plays an important role in renal IRI. Up-regulation of CDlla further elucidates the mechanism of relation between IRI and acute rejection: more heavier IRI is, more possible acute rejection would be.
