CHANGE OF EXTRACELLULAR-SIGNAL REGULATED-PROTEIN KINASE1/2 SIGNALING PATHWAY IN SKIN AT DIFFERENT DEVELOPMENT STAGES
- VernacularTitle:细胞外信号调节激酶1/2传导通路在不同发育阶段皮肤组织内的变化
- Author:
Wei CHEN
;
Xiaobing FU
;
Tongzhu SUN
- Publication Type:Journal Article
- Keywords:
extracellular-signal regulated-protein kinasel/2;
signal transduction;
fetal skin
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study was to investigate the localization and expression characteristics of phosphorylated form of extracellular-signal regulated-protein kinasel/2 (p-ERKl/2), Ras and C-fos in skin at different development stages and to explore their potential biological significance. Immunohistochemistry and pathological methods were used to detect the expression intensity and distribution of p-ERKl/2, Ras and C-fos in skin of 8 fetuses with different gestational ages (13 to 31 weeks) and 8 adults. Positive immunohistochemical signals of p-ERK1/2, Ras and C-fos. could be found in fetal and postnatal skins. Along with the increment in gestational age, the positive cell rates of p-ERK1/2, Ras and C-fos in the skin elevated progressively. In skins derived from the fetus of late-trimester pregnancy and adult, the positive rates of these three proteins were significantly increased in comparison with skin from the early-trimester fetus (P
