CHANGES OF RENIN-ANGIOTENSIN SYSTEM IN KIDNEY OF AGED RATS AND THE REGULATIVE EFFECTS OF VALSARTAN
- VernacularTitle:衰老大鼠肾脏肾素-血管紧张素系统的变化及缬沙坦的调控作用
- Author:
Li ZHANG
;
Xiangmei CHEN
;
Lixia PENG
- Publication Type:Journal Article
- Keywords:
aging;
renin-angiotensin system;
renal agents
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the changes of local RAS in kidney of aged rats and the regulative effect of AT1 RA, sixteen-month-old male Wistar rats were treated with the valsartan (25mg/kg) until sacrificed at the age of 24 months, and their results were compared with young and aged controls. Renin, angiotensinⅡ levels and the expressions of ATlaR mRNA, AT1bR mRNA and AT2R mRNA were measured. The results showed that plasma renin and angiotensin Ⅱ levels decreased with aging, whereas angiotensin Ⅱ in kidney cortex increased. Valsartan increased the angiotensin Ⅱ level of the aged kidney significantly . AT1aR mRNA and AT1bR mRNA were down-regulated in aged rats compared with the young group. The expression of AT2R mRNA was up-regulated with aging. Valsartan increased AT1aR mRNA, but did not modify AT1b R mRNA and AT2 R mRNA. This results indicated that angiotensin Ⅱ receptors were regulated differently with aging. Our conclusion is that in rat kidney valsartan increases renal angiotensinⅡlevel, blocks AT1R, but has no effect on gene expression of AT2R, which might enhance the protective effect by the stimulation of AT2R.
