DETERMINATION OF S-100 BETA PROTEIN AND NEURON-SPECIFIC ENOLASE OF CEREBROSPINAL FLUID IN PATIENTS WITH CENTRAL NERVOUS SYSTEM INFECTIONS
- VernacularTitle:中枢神经系统炎症患者脑脊液S-100B蛋白和神经元特异性烯醇化酶含量的测定
- Author:
Gang ZHAO
;
Yining YANG
;
Xiuchu SU
- Publication Type:Journal Article
- Keywords:
S-100 protein;
neuron-specific enolase;
cerebrospinal fluid;
central nervous system, infections
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the value of assessment in measuring S-100 beta protein (S-100B protein) and neuron-specific enolase (NSE) present in cerebrospinal fluid (CSF) from patients with brain insult in central nervous system infections, S-100B protein and NSE in CSF were measured dynamically by ELISA in 42 patients with Herpes Simplex Encephalitis (USE), 19 patients with purulent meningitis, 17 patients with cryptococcus meningitis and 22 unrelated control patients. It was found that the levels of CSF S-100B protein in all the three groups were higher than that of the control group (P0. 05). There were dynamic changes of CSF S-100B protein and NSE concentrations in all three groups correlating with the severity of disease. It is suggested that elevated concentrations of S-100B protein and NSE in CSF related to the damage of glia and neurons could be used as CSF markers of brain insult in patients with central nervous system infections.
