DISTRIBUTION AND RADIORECEPTORIMAGING OF ~131I-LABELED ANGIOSTATIN IN TUMOR-BEARING MICE
- VernacularTitle:~(131)I-angiostatin在荷瘤小鼠体内的分布及放射受体显像
- Author:
Menghui YUAN
;
Haifeng XU
;
Fuyang LI
- Publication Type:Journal Article
- Keywords:
angiogenesis inhibitors;
lung neoplasms;
tissue distribution: radioreceptor imaging;
mice
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To provide an evidence for clinical application, the distribution and radioimmunoimaging of 131I-labeled angiostatin in tumor-bearing mice were studied. Angiostatin was labeled with 131 I by the conventional chloramines T (Ch-T) method and injected into C-57 mice bearing Lewis lung cancer. The biodistribution of 131 I-angiostatin and whole body ECT imaging were studied at various intervals after injection. The average percentage of ID/g was 12. 48, 18. 56 and 23. 17 for tumor and 7. 04 ,5. 47 and 1. 73 for liver at 48, 96, 144 hours postinjection, respectively. The T/NT ratios were 1. 77, 3. 39 and 13. 39 for liver at 48 ,96 and 144 hours postinjection, respectively. The tumor was showed clearly at 96 hours after injection . The quality of tumor imaging was relevant to the T/NT ratio . The results demonstrated that the 131I-angiostatin binds specifically to the receptor on endothelial cells in the tumor and may also possess the capability of locating lung cancer tissue.
