STUDY ON APOPTOSIS OF FffiROBLASTS DERIVED FROM THE SURROUNDING SKIN OF KELOIDS
- VernacularTitle:瘢痕疙瘩周围皮肤成纤维细胞凋亡的实验研究
- Author:
Hongjie DUAN
;
Jianhua GAO
;
Guangyu SHEN
- Publication Type:Journal Article
- Keywords:
keloid;
surrounding skin;
fibroblasts;
apoptosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate if there are abnormal fibroblasts derived from the skin surrounding keloids in order to have a better understanding for keloid progression. All the samples were used for cell culture. Flow cytometry was used to compare the apoptotic rate of fibroblasts derived from keloid and its surrounding skin, when it was cultured in serum-deprived medium for 24 hours or was induced by Fas antibody. After cultured in serum-deprived medium for 24 hours, the apoptotic rate of fibroblasts derived from the surrounding skin of keloid increased to an amount between that of normal skin and keloids. The apoptotic rate of normal skin fibroblasts increased more than that of keloids. Moreover, when induced by Fas antibody, the apoptotic rate of fibroblasts derived from the surrounding skin increased not so high as that of normal skin(P0. 05). Therefore, at least there are some fibroblasts in the surrounding skin of keloids, in which apoptosis can not be induced as in normal skin.
