Urinary Trypsinogen Activation Peptide (TAP) levels in the patients with acute pancreatitis
- VernacularTitle:急性胰腺炎患者尿中胰蛋白酶原激活肽水平的变化
- Author:
Qun QIAN
;
Congqing JIANG
;
Lifang FAN
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Trypsinogen activation peptide
- From:
Journal of Clinical Surgery
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of urinary Trypsinogen Activation Peptide (TAP) levels in patients with acute pancreatitis (AP).Methods We observed the association between urinary TAP concentration and severity of acute pancreatitis with competitive enzyme-linked immunosorbent assay(ELISA). Urine samples were collected for TAP concentration at admission,24,48,and 72 h from 57 patients with AP who presented within 48 h of the onset of symptoms and from 11 control patients. Results The median urinary TAP at admission for severe acute pancreatitis(SAP) (98 nmol/L) was signficantly higher than the median for both mild pancreatitis (22 nmol/L,P0.05).The peak median urinary TAP in severe eroup was seen at admission.In the following days,TAP concentrations decreased graduallg.Conclusion Breakthrough activation of trypsinogen in pancreatic interstitial and blood may be the key event in the development of SAP.
