SIGNIFICANCE OF CHANGES IN HIGH MOBILITY GROUP-1 PROTEIN IN RATS WITH POSTBURN STAPHYLOCOCCUS AUREUS SEPSIS AND ITS POTENTIAL SIGNAL TRANSDUCTION PATHWAY
- VernacularTitle:烫伤后金葡菌脓毒症大鼠高迁移率族蛋白-1表达及其信号调节机制
- Author:
Hongyun LI
;
Yongming YAO
;
Nin DONG
- Publication Type:Journal Article
- Keywords:
burns;
high mobility group 1 protein;
Staphylococcus aureus;
sepsis;
signal transduction
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate changes in high mobility group 1 (HMG 1) protein in postburn Staphylococcus aureus infection and its potential signaling mechanism. A total of 61 male Wistar rats were randomly divided into four groups as follows: normal control group ( n =6), scald control group ( n =9), postburn sepsis group ( n =36) and rapamycin (RPM) treatment group ( n =10). Tissue samples from the liver and kidney were collected to determine tumor necrosis factor ? (TNF ?) and HMG 1 mRNA expression. The results showed that, after Staphylococcus aureus challenge, TNF ? mRNA expression was up regulated rapidly in both the liver and the kidney, peaking at 2 hours ( P
