THE SIGNIFICANCE AND POTENTIAL ROLE OF SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION 3(STAT3)ACTIVATION IN POSTBURN STAPHYLOCOCCUS AUREUS SEPSIS
- VernacularTitle:烫伤脓毒症大鼠肝、肺组织STAT3活化规律及意义
- Author:
Sheng YAO
;
Yongming YAO
;
Hongyu LI
- Publication Type:Journal Article
- Keywords:
sepsis;
burns;
Staphylococcus aureus;
signal transducers and activators of transcription 3;
interferon gamma
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study was performed to investigate the significance and potential role of signal transducers and activators of transcription 3 (STAT3) activation in postburn Staphylococcus aureus sepsis. Seventy one male Wistar rats were randomly divided into five groups: normal controls, scald control group, postburn sepsis group, AG490 (JAK2 inhibitor) treatment group, and rapamycin (RPM, STAT3 inhibitor) treatment group. Tissue samples from the liver and lung were collected to determine activation of STAT3, and interferon ? (IFN ?) mRNA as well as protein expression. The results showed that activation of STAT3 was quickly up regulated at 0 5～1 hour following thermal injury combined with Staphylococcus aureus challenge in the liver and lung, and it gradually weakened after 2 hours. Treatment with AG490 or RPM could inhibit activation of STAT3 at 0 5 hour in the liver and lung. Meanwhile, IFN ? mRNA expression markedly declined at 2 hours after treatment with AG490 or RPM in the liver and RPM in the lung ( P
