THE SIGNIFICANCE OF CHANGES IN TISSUE SUPPRESSORS OF CYTOKINE SIGNALING IN RATS WITH SEPSIS INDUCED BY CECAL LIGATION AND PUNCTURE
- VernacularTitle:脓毒症大鼠组织中细胞因子信号转导抑制因子表达的研究
- Author:
Hongyun LI
;
Yongming YAO
;
Nin DONG
- Publication Type:Journal Article
- Keywords:
suppressor of cytokine signaling;
endotoxin;
tumor necrosis factor;
sepsis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to observe the changes in tissue suppressors of cytokine signaling (SOCSs) mRNA expression, and to investigate their potential role in the pathogenesis of sepsis induced by cecal ligation and puncture (CLP). Fifty four Wistar rats were randomly divided into three groups: normal control group ( n =6), CLP induced sepsis group ( n =36) and recombinant bactericidal/ permeability increasing protein (rBPI 21 ) treatment group ( n =12). Tissue samples from the liver, lung and kidney were collected to determine SOCS1 and SOCS3 mRNA expressions. Meanwhile, tissue endotoxin and TNF ? levels were also determined. The results showed that, after CLP, endotoxin and TNF ? levels in the liver, lung and kidney significantly increased, peaking at 2～12h ( P
