THE ROLE OF CALCINEURIN-DEPENDENT SIGNAL PATHWAY IN CARDIAC HYPERTROPHY OF COLD STRESS-INDUCED HYPERTENSIVE RATS
- VernacularTitle:钙调神经磷酸酶在冷应激高血压大鼠心肌肥厚中的作用
- Author:
Changqing YU
;
Zhiming ZHU
;
Lijua WANG
- Publication Type:Journal Article
- Keywords:
phosphatases;
stress;
hypertension;
cardiomyopathy, hypertrophic
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the role of calcineurin dependent signal pathway in cardiac hypertrophy of cold stress induced hypertensive rats, 3 months old Wistar rats were exposed to cold (4?2℃) for 4 hours per day for 8 weeks to produce cold stress induced hypertension and cardiac hypertrophy. The systolic blood pressure(SBP), heart rate and hemodynamic parameters were measured using a force transducer.The heart/body weight ratio, CaN activity, CaN, c fos expression protein of cardiac tissure were also investigated. The results showed that SBP and heart rate in cold stress rats were significantly increased than that in nomal rats during the whole experiment( P
