The effect of interventional treatment on the expression of drug-resistance gene in primary lung carcinomas
- VernacularTitle:介入治疗对耐药基因在原发性肺癌表达的影响
- Author:
Gang SUN
;
Peng JIN
;
Zonggui XIE
;
Ming GENG
;
Yuhai YI
- Publication Type:Journal Article
- Keywords:
Carcinoma, non small cell lung;
Carcinoma, small cell;
Radiology, interventional;
Drug, resistance;
Immunohistochemistry
- From:
Chinese Journal of Radiology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of interventional treatment on the expression of PgP and GST ? in different histopathological types of primary lung carcinoma. Methods One hundred and eighteen cases of histopathologically verified primary lung carcinoma were studied. SCLC was found in 26 cases and NSCLC in 92 cases. The non chemotherapy group had 50 cases, and the interventional treatment group had 68 cases. PgP and GST ? were examined in all specimens with 2 step immunohistochemistry. Results The positive expression rates of PgP and GST ? were 32.0% and 34.0% in non chemotherapy group, respectively, 75.0% and 78.6% in interventional treatment with non embolization group, respectively, and 50.0% and 52.5% in interventional treatment with embolization group, respectively. The positive expression rates of PgP and GST ? had significant difference between non chemotherapy group and interventional treatment with non embolization group( P 0.05). There was a tendency of positive correlation between differentiated degree of carcinoma and the expression of PgP and GST ? in NSCLC. Condusion To detect PgP and GST ? in carcinoma tissue is important and has the instructive significance for chemotherapy of lung carcinoma. The positive rate of multidrug resistant gene is obviously increased in the primary lung carcinoma with bronchial arterial chemotherapy. The inducement to multidrug resistance gene in bronchial arterial embolization with the emulsifying agent of oil anticarcinogen was lower.
