Role of CD38~+CD8~+ T lymphocyte on monitoring cytomegalovirus infection after kidney transplantation
- VernacularTitle:测定CD38~+CD8~+T淋巴细胞在监测肾移植后巨细胞病毒感染中的作用
- Author:
Jiguang FEI
;
Peigen WU
;
Lizhong CHEN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Cytomegalovirus infection;
T lymphocyte;
Leucocyte antigen
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the levels of CD38+CD8+ T lymphocyte in kidney transplant recipients with cytomegalovirus infection and investigate the possibility in monitoring the cytomegalovirus active infection after kidney transplantation. Methods Before and after kidney transplantation, CD38+ CD8+T lymphocyte and cytomegalovirus leucocyte antigen were measured respectively by flow cytometry and immunohistochemistry method in 56 transplant recipients. The data of CD38+CD8+ T lymphocyte and the cylomegalovirus leucocyte antigen were analyzed. Results Before kidney transplantation, cytomegalovirus leucocyte antigen was negative among all the patients, while the mean ratio of (CD38+CD8+)/CD8+ was 0. 11?0. 05. In 14 recipients whose cytomegalovirus leucocyte antigen was positive, the appearing time of the positive antigen was(32. 7?16. 6) days of post-transplantation, meanwhile, the mean ratio of (CD38+ CD8+)/CD8+ was 0. 43?0. 21 (29. 6?8. 4) days of post-transplantation, which was significantly higher than that of pre-transplantation. After the treatment with ganciclovir intravenously, the cytomegalovirus leucocyte antigen became negative and the mean ratio of (CD38+CD8+)/CD8+ decreased to 0. 16?0.09 which was significantly lower than that of pre-treatmmt ( P
