Pharmacodynamics of paclitaxel long-circulating thermo sensitive liposomes in Lewis tumor-bearing mice
10.3969/j.issn.1006-5725.2014.14.003
- VernacularTitle:紫杉醇长循环热敏脂质体对Lewis肺癌荷瘤鼠的药效学研究
- Author:
Meibo LI
;
Shengjiu GU
;
Wenpeng ZHAO
;
Kaimei ZHU
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Long-circulating thermo sensitive liposomes;
Thermo sensitivity liposomes;
Hyperthermia
- From:
The Journal of Practical Medicine
2014;(14):2193-2195,2196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the tumor inhibition effect of paclitaxel long-circulating thermo sensitive liposomes (PLTL) in mice bearing Lewis lung carcinoma cells. Methods A tumor-bearing mouse model was established, and the mice were randomly divided into five groups: control, heating, paclitaxel (PTX), paclitaxel thermo sensitive liposomes (PTL), and PLTL groups. The living status was observed in the mice. The volume and weight of the tumor were measured. The morphological changes in the tumor cells were observed f by HE staining and apoptosis of the tumor cells was determined by flow cytometry. Results The inhibition rate of tumor in PTX, PTL and PLTL groups was 48.87%, 57.22%and 78.87%, respectively. The apoptotic rate of tumor cell in PTX, PTL and PLTL groups was (42.7 ± 3 .8)%, (54.6 ± 2.9)%and (69.7 ± 5.0)%, respectively. Conclusions PLTL, as compared with PTX and PTL, has an evident thermo sensitive feature and increases the anticancer effect of paclitaxel remarkably in combination with local hyperthermia.
