Clinical observation of leflunomide and glucocorticoids in treatment of chronic nephritis
- VernacularTitle:来氟米特联合糖皮质激素治疗慢性肾小球肾炎的临床疗效观察
- Author:
Xianwen LUO
- Publication Type:Journal Article
- Keywords:
leflunomide;
glucocorticoids;
chronic nephritis;
clinical efficacy
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):160-161,164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate therapeutic effect of Leflunomide combined with glucocorticoids on patients with chronic nephritis.Methods 36 patients with chronic nephritis in Guangyuan Hospital of Traditional Chinese Medicine from January 2012 to October 2013,were randomly divided into two groups:the routine group were treated with conventional therapy;While the theraputic group were treated by leflunomide and glucocorticoid.The tests of urinary protein,serum cretonne and blood urea nitrogen were conducted during treatment in both groups. Results The total effective rate was 88.89 %in the treatment group and 72.2% in the control group.the difference was significant(P<0.05 ).After treatment,measured value of urine protein, serum cretonne and blood urea nitrogen were significantly higher than prior treatment(P<0.05 ).Conclusion The therapeutic effect of leflunomide combined corticosteroid on chronic nephritis is better.
