EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF BDNF ON HYPOXIC ISCHEMIC ENCEPHALOPATHY IN NEONATAL RATS
- VernacularTitle:脑室注射脑源性神经营养因子对新生大鼠缺氧缺血性脑损伤的影响
- Author:
Xinru HONG
;
Ling ZHENG
;
Jia SHI
- Publication Type:Journal Article
- Keywords:
brain derived neurotrophic factor;
brain ischemia;
brain hypoxia;
rat,newborn
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effects of brain derived neurotrophic factor (BDNF) on hypoxic ischemic encephalopathy in neonatal rats,0 2, 0 5 or 2 0?g of BDNF was injected into cerebroventricles of 7d neonatal Sprague Dawley rats with hypoxic ischemic encephalopathy by ligation of left common carotid artery and 2 5h inhalation of humidified 8% O 2 +92% N 2 at 37℃. Its effects on brain edema, levels of malondialehyde (MDA) and neuronal apoptosis at the left cortex and hippocampus were observed. The results showed that brain edema was markedly alleviated in 0 5?g group compared to the vehicle group 24h after BDNF injection. Levels of MDA in the left hemisphere in 2 0?g group were significantly higher than those in either vehicle group or 0 5?g group. Neuronal apoptosis decreased to a different extent in the three groups while obviously in both 0 2?g and 0 5?g groups. It is suggested that BDNF exerts a prominent protective effect on hypoxic ischemic encephalopathy in neonatal rats, but this effect is lowered when overdose is injected.
