PREPARATION AND RELATED STUDY OF DECALCIFIED BONE MATRIX PARTICLES WITH ADRIAMYCIN IMPREGNATED BONE CEMENT DRUG DELIVERY SYSTEM IN VIVO
- VernacularTitle:阿霉素异体脱钙骨基质骨粒骨水泥缓释体的制备及体内释药实验
- Author:
Wei YU
;
Yong ZHOU
;
Qingy FAN
- Publication Type:Journal Article
- Keywords:
adriamycin;
bone cement;
drug delivery system;
bone neoplasms
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To prepare decalcified bone matrix particles(DBMP)with adriamycin(ADM) impregnated bone cement(BC) drug delivery system(DDS), its drug delivery characteristics were studied and analysed in vivo. DBMP were made according to the methods of Urist et al. ADM was putting into DBMP by vacuum absorption and freeze drying techniques. Then the DBMP with ADM were impregnated into BC in 1∶1 to form DDS. The DDS was implanted into the greater trochanter of femur in rabbits and the release test was done in vivo. The DDS could gradually release ADM for over 12 weeks in local bone tissues, maintained stable release for 4 weeks. The maximum ADM in local bone tissues was 29 times higher than that of the same intrarenous dose, while the maximum ADM in plasma was only 1/10 of the same intravenous dose. The DDS has a good sustained release function, and can meet the needs of local chemotherapy for limb salvage treament of bone tumor.
