EFFECT OF LOCAL MILD HYPOTHERMIA ON THE ACTIVITY OF CALCINEURIN IN ISCHEMIC CEREBRAL TISSUE IN RATS
- VernacularTitle:局部亚低温对大鼠脑缺血组织钙调神经磷酸酶活性的影响
- Author:
Xuzheng CAO
;
Jie LAN
;
Jianmi XU
- Publication Type:Journal Article
- Keywords:
calcineurin;
mild hypothermia;
cerebral ischemia
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the protective effect of local mild hypothermia on the ischemic cerebral tissue, a model of middle cerebral artery(MCA) occlusion was prepared in Wistar rats which were randomly divided into the normal temperature group, FK 506 group, mild hypothermia group and control group. The radioactivity of calcineurin in ischemic cerebral tissue was measured in different time after MCA occlusion. The activity of calcineurin decreased 6 hours after ischemia in the normal temperature group and the FK 506 group, whereas no obvious change of calcineurin activity was observed in the mild hypothermia group, which had a significant difference. It is suggested that the local mild hypothermia treatment may inhibit the change of calcineurin activity in ischemic cerebral tissue, and has a tangible protective effect on the ischemic brain.
