The proliferation and apoptosis of smooth muscle cells after implantation of NiTi radioactive stents in the rabbits' aortas
- VernacularTitle:NiTi放射性支架置入兔腹主动脉后对平滑肌细胞增殖和凋亡的影响
- Author:
Yonghui CHI
;
Yayan BI
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
Radioactive stents Restenosis PCNA TUNEL SMCs
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the proliferation and apoptosis of smooth muscle cells(SMCs) after implantation of NiTi radioactive stents. Methods Radioactive and nonradioactive stents were implanted in abdominal aortas of 76 rabbits.The proliferation and apoptosis of SMCs were observed using immunohistochemistry and TUNEL.Results (1) Neointima areas on radioactive stents were less than those on nonradioacvtive stents at 1-month and 3-month respectively (P0 05).(2)The expressions of PCNA were lower in radioactive stent groups at different times compared with those of controls(P0.05).Conclusions (1) Radioactive stents can reduce the neointima areas on the implanted stents.(2)Radioactive stents can inhibit the proliferation of SMCs.(3)Radioactive stents promote the apoptosis of SMCs.
