Internittent hypoxic preconditioning effects EPO in the remaining liver after major hepatectomy

VernacularTitle:间断低氧预适应对大鼠肝切除缺血再灌注肝脏中EPO的影响
Author: Pengfei LI ; Jian WANG ; Xiaofan HAN ; Shichun ZHU ; Guang LI ; Peijian ZHANG
Publication Type:Journal Article
Keywords: Intermittent hypoxia preconditioning; Hepatectomy; Erythropoietin; Enzyme-linked immunosorbent assay; Vena cava,inferior
From: International Journal of Surgery 2014;41(5):311-315,封3
CountryChina
Language:Chinese
Abstract: Objective To observe the effects of intermittent hypoxic preconditioning on the expression of apoptosis-related EPO after 70％ hepatectomy combined with ischemia-reperfusion injury.Methods One hundred and twenty healthy SD rats of clean grade,simple random divided into 3 groups:Sham operation group of 40 rats ; Pure major hepatic resection group was 40 (Major hepatectomy,MH),namely in the hepatic portal blocking liver resection of the left and middle lobes,hepatic portal blocking 20 min ; intermittent hypoxia preconditioning group 40 (Intermittent hypoxia preconditioning,IHP group).Results MH group,S group,IHP group,EPO level in three experimental groups in postoperative residual liver tissue in rats with significant difference (P ＜ 0.05),Intermittent hypoxia preconditioning group of residual liver EPO content was significantly higher than that of simple hepatic resection group 40.Conclusion Intermittent hypoxia preconditioning can promote the expression of residual liver after hepatectomy in EPO.