Acute kidney injury and cell cycle regulation
10.3760/cma.j.issn.1673-4408.2014.03.030
- VernacularTitle:急性肾损伤与细胞周期调控
- Author:
Yunlin SHEN
;
Wenyan HUANG
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Cell cycle;
Cell cycle regulatory protein;
Cell cycle checkpoint
- From:
International Journal of Pediatrics
2014;41(3):331-333,336
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury(AKI) has emerged as a major public health problem that leads to decreased survival.In AKI,cell hyperplasia,hypertrophy and apoptosis are related to the cell cycle control.Two supervisory restriction points,G1/S and G2/M checkpoints,are responsible for cell-cycle control.Furthermore,cell cycle regulatory proteins are also involved in the regulation of the cell cycle in AKI.This review focuses on the cell cycle regulation mechanism of AKI.
