CHARACTERISTICS OF Fas, Fas-L AND Caspase-3 EXPRESSION IN HYPERTROPHIC SCARS AND THEIR EFFECTS ON SCAR FORMATION
- VernacularTitle:Fas,Fas-L和Caspase-3在增生性瘢痕中表达特征及其对瘢痕形成的影响
- Author:
Wei CHEN
;
Xiaobing FU
;
Tongzh SUN
- Publication Type:Journal Article
- Keywords:
scar;
skin;
immunohistochemistry;
antigens, CD95
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the different expression of Fas, Fas L and Caspase 3 in hypertrophic scars and normal skins in order to explore their influences on scar formation, the expression intensity and distribution of Fas, Fas L and Caspase 3 were detected by immunohistochemistry and pathological methods in 8 cases of hypertrophic scars and 8 cases of normal skins. In normal skins, Fas and Fas L were mainly located in the cellular membranes and cytoplasms of epidermal cells and some fibroblasts. Caspase 3 was mostly distributed in epidermal basal cells and some fibroblasts. In hypertrophic scars, Fas and Fas L were principally existed in the membranes and cytoplasms of epidermal keratinocytes. The positive cellular ratio of two proteins was significantly reduced ( P
