CHANGES OF DOPAMINE RECEPTOR ACTIVITY IN CAUDALPUTAMEN OF PARKINSON DISEASE RAT MODEL
- VernacularTitle:帕金森病大鼠模型尾壳核多巴胺受体活性的变化
- Author:
Wangming ZHANG
;
Ruxiang XU
;
Yingqia CAI
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
oxidopamine;
receptors,dopamine;
rats
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the role and changes of dopamine receptor activity and their subtypes during the onset process of Parkinson disease( PD ), on the basis of 6 hydroxydopamine lesioned PD rat model, radioligand binding assay (RLBA) and Scanchard drawing were used to measure the maximal binding capacity of receptor (Bmax) and equilibrium dissociation constant (KD) of D 1 and D 2 dopamine receptors in caudal putamen of the model and control rats at different time point. The results of RLBA study revealed D 2 dopamine receptor Bmax was significantly increased and KD was significantly decreased in the caudal putamen ipsilateral to the lesion in rat model, and the changes reached the peak in one month rat model group. In contrast, the caudal putamen D 1 receptors were far less affected, with no consistent changes in the same model groups as compared with the control, except that 2 weeks model group showed Bmax was slightly decreased while KD was slightly increased. The study confirms that D 2 dopamine receptor is upregulated in the caudal putamen ipsilateral to the lesion in PD rat model, and the affinity of the receptors is increased, but the activity of D 1 dopamine receptor is not significantly changed.
