EFFECT OF HIGH CONCENTRATION GLUCOSE AND AGEs ON VCAM-1 EXPRESSION OF MOUSE CARDIAC MICROVASCULAR ENDOTHELIAL CELLS
- VernacularTitle:高糖、晚期糖化终产物对微血管内皮细胞VCAM-1表达的影响
- Author:
Maojin XU
;
Dajin ZOU
;
Jianghong YE
- Publication Type:Journal Article
- Keywords:
glucose;
AGEs;
VCAM 1;
endothelium, vascular
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effect of high concentration glucose and AGEs on VCAM 1 expression of mouse cardiac microvascular endothelial cells, the VCAM 1 expression was measured by using FACS after the endothelial cells were incubated with high concentration glucose, AGEs alone or combined respectively, the TNF ? level of cultured medium was measured by using RIA. The results showed that the VCAM 1 expression and TNF ? level increased significantly in high concentration glucose and AGEs group and increased more over in combined group. It is suggested that High concentration glucose and AGEs could induce the VCAM 1 expression, and has synergistic action. The increased level of TNF ? coincident with the increased VCAM 1 expression,is probably one of the factors in the mechanism of increased VCAM 1 expression.
