Effects of recombinant rat augmenter of liver regeneration on proliferation and secretion of transforming growth factor ft in glomerular mesangial cells
- VernacularTitle:重组大鼠肝再生增强因子对系膜细胞增殖及分泌转化生长因子?的影响
- Author:
Ling ZHANG
;
Tinghai HU
;
Qi LIU
- Publication Type:Journal Article
- Keywords:
Hepatocyte growth factor;
Glomerular mesangial cell;
Transforming growth factor ?
- From:
Chinese Journal of Nephrology
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of recombinant rat augmenter of liver regeneration (rrALR) on the biological activities of rat glomerular mesangial cell(GMC) with or without IL-1?. Methods GMC proliferation and the level of TGF-? protein were determined by 3H-TdR incorporation and ELISA. Results The stimulating activity of IL-1? to rat GMC was enhanced by rrALR with the concentrations from 0.005 pg/ml to 0. 1ng/ml. But rrALR could not promote the proliferation of GMC without IL-1?. Conclusion rrALR may be a new mediator of inflammation, which promote proliferation and TGF-? secretion in rat GMC stimulated by IL-1?.
