Hereditary IgM nephropathy: report of three cases in a kindred and review of literatures
- VernacularTitle:遗传性IgM肾病一家系三例报告及文献复习
- Author:
Hang LI
;
Xuewang LI
;
Yanyan HE
- Publication Type:Journal Article
- Keywords:
IgM nephropathy;
Heredity
- From:
Chinese Journal of Nephrology
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To recognize hereditary IgM glomerulopathy. Methods Three patients with hereditary IgM glomerulopathy were report first time in China. Genealogic investigation and light, immunofluorescence and electron microscopy were performed. Literatures concerned were reviewed. Results Kidney biopsies from three patients all revealed diffuse mesangial proliferative glomerulonephritis with intense IgM and C3 deposits. These siblings might be suffering from a hitherto undescribed clinico-pathological entity. Genealogic investigation enabled us to discover 10 additional affected members with clinical glomerulonephritis in the kindred of the family. The clinical picture was that of hematuria and/or proteinuria, meanwhile one patient died of uremia. Conclusion Genetic factors may be involved in the mechanism of IgM nephropathy .
