EXPERIMENTAL STUDY OF CAPRINE TIBIA DIAPHYSEAL DEFECT REPAIRED WITH THE TISSUE ENGINEERING METHOD
- VernacularTitle:用组织工程方法修复山羊胫骨骨缺损的实验研究
- Author:
Ke WANG
;
Guoxian PEI
;
Bi CHEN
- Publication Type:Journal Article
- Keywords:
biomedical engineering;
bone defect;
coral hydroxyapatite;
bone marrow stroma cell;
goats
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To prepare an experimental caprine model of tibia bone diaphyseal defect used in tissue engineering and defect repair with the tissue engineering method, 27 Chinese caprines were divided into 3 groups: blank, control, and test. The 20mm left tibia diaphyseal defect of each caprine was made and fixed with plates. The blank group was not filled with coral hydroxyapatite (CHAP) or bone marrow stroma cell (BMSc). The control group and the experimental group were filled with CHAP and CHAP/BMSc respectively. The results of three groups were evaluated by X ray examination, optical density index of X ray film and histology 4, 8, 12 weeks after operation. The biomechanical characteristics of the specimens of the CHAP group and the CHAP/BMSc group were tested by three point bending test 12 weeks after operation.The results showed that the optical density indices of X ray film of the blank group were not significantly different 4, 8, 12 weeks after operation and indices of the CHAP group were significantly smaller than those of the CHAP/BMSc group ( P
