EXPRESSIONS OF ALPHA-SMA, PAI-1, MMP-9 AND TIMP-1 IN RENAL VESSELS OF PATIENTS WITH IGA NEPHROPATHY
- VernacularTitle:IgA肾病肾血管纤溶酶原激活物抑制物-1和基质金属蛋白酶-9的表达及其意义
- Author:
Jianzhong WANG
;
Xiangmei CHEN
;
Suozh SHI
- Publication Type:Journal Article
- Keywords:
glomerulonephritis IgA;
plasminogen activator inhibitor 1;
matrix metalloproteinase 9;
tissue type inhibitor of metalloproteinase 1
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore expressions of ? smooth muscle actin (? SMA), plasminogen activator inhibitor 1 (PAI 1), matrix metalloproteinase 9 (MMP 9)and tissue type inhibitor of metalloproteinase 1 (TIMP 1) in renal vessels of 38 patients with immunoglobulin A nephropathy (IgAN), immunohistochemistry method was used to detect abundances of the above proteins. The results showed that ? SMA staining was found mainly in vascular smooth muscle cells (SMCs); apparent PAI 1 staining was also shown by vascular SMCs; MMP 9 expressed considerably in vascular both SMCs and endothelial cells; TIMP 1 was located only in vascular endothelial cells. In renal tissues of IgAN patients at Lee IV V grade, vascular expressions of ? SMA?PAI 1 and MMP 9 were significantly higher than those at Lee I III grade ( P
