ALTERATIONS OF CONTRACTILE FUNCTION OF VSM AND IT′S MECHANISM IN HEMORRHAGIC SHOCK RATS
- VernacularTitle:失血性休克后大鼠血管平滑肌舒/缩功能变化及其机制
- Author:
Qisheng JIANG
;
Deyao HU
;
Na XIAO
- Publication Type:Journal Article
- Keywords:
vascular smooth muscle;
contraction;
shock
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the alterations of contractile function of VSM and it's primary mechanism in hemorrhagic shock rats, contractile tension of vascular rings induced seperately by NE,PE,Caffeine and K + was measured with tension conductor and physiological recorder. The results showed that after 2h and 4h of shock, contractile tension of vascular rings to NE was 76 17% and 66 50% as compared to the control group; contractile tension to 20 mmol/L caffeine and over 20 mmol/L K + was significantly decreased after 2h of shock;and decreased to 3?10 -6 M PE after 4h of shock. The data suggested that contractile tension of VSM would decrease after shock and it maybe at least in part related to the decreased function of both calcium influx from ex cells and calcium release from sarcoplasmic reticulum of vascular smooth muscle cells.
