STUDY ON RELATION OF LAMININ RECEPTOR AND DIFFERENT BILE DUCT CARCINOMA METASTATIC CELL STRAINS
- VernacularTitle:层粘连蛋白受体与胆管癌细胞不同转移性亚群的关系研究
- Author:
Canghong CHEN
;
Shuguang WANG
;
Dajian LI
- Publication Type:Journal Article
- Keywords:
cholangiocarcinoma;
receptor, laminin;
neoplasm metastasis
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of laminin receptor in different bile duct carcinoma cell strains, a peritoneum infiltration screening model was established to screen out the different metastatic cell strains of bile duct carcinoma. Invasive experiments in vitro were adopted to validate the results. The difference of LNR expression was compared both in the high and low cell strains by flow cytometry analysis. The results showed that by using the peritoneum infiltration screening model, high and low metastatic QBC939 cell strains were successfully screened out. Invasive experiments in vitro also proved that the invasive ability of high cell strain was stronger than that of the low one. The positive rate of LNR in high strains (36 36?9 22)%was higher than that in the low ones(13 17?3 43)%, and the difference was significant( P
